Tenpoint Therapeutics, Ltd.’s YUVEZZI (carbachol and brimonidine tartrate ophthalmic solution) 2.75%/0.1% has officially made its debut in the U.S. commercial market—just 2 months after the FDA’s approval.
Big news! Let’s start with the basics.
What it is: A proprietary, pupil-modulating and fixed-dose eye drop that reduces the pupil size to allow only centrally-focused rays to enter the eye.
How it’s doing this: Via two dual-agent active ingredients (see below) that work together to target two different but complementary mechanisms of action (MOA), offering rapid symptom relief and long-term disease management.
- Brimonidine tartrate
- Carbachol
Explain how these work together.
Check out this rundown on the unique properties associated with brimonidine tartrate (a highly-selective alpha-2 agonist) and carbachol (a cholinergic and miotic agent).
Hint: It involves a prolonged “pinhole effect” that reduces pupil size for near-visual acuity improvement and a longer duration of action.
Next up: dosing and timing on those effects.
YUVEZZI is formulated for once-daily (in each eye) topical instillation via a single-dose vial.
- See here for recommendations if wearing contact lenses.
As for its effects: Miosis should kick in around 30 minutes following instillation.
- The duration: Up to 10 hours.
Speaking of that duration … what’s the supporting data behind this?
That would be phase 3 clinical findings from two studies (BRIO I and BRIO II) that went above and beyond the FDA’s requirements for approval of a fixed-dose combination.
Check out this brief recap of that data.
And for a more detailed breakdown:
Now for a closer look at its prescribing information.
The full prescribing information (PI) can be viewed here.
- For adverse reactions observed in those aforementioned clinical trials, see here.
- For warnings and precautions, click here.
- And for contraindications, click here.
So! How can patients get a hold of this?
For qualifying patients (considering YUVEZZI is prescription-based), the drop is available directly via two options:
- PHILRx (a national mail-order specialty pharmacy partner)
- 30 single-use vials reportedly clock in at $79
- Retail pharmacies (see here for varying pricing)