Published in Pipeline

Endogena Therapeutics completes enrollment ahead of schedule in phase 1/2a trial of EA-2353 for RP

Endogena Therapeutics Inc. announced that it has completed patient enrollment ahead of schedule in its Phase 1/2a trial of EA-2353 for the treatment of retinitis pigmentosa (RP).

With the dose-escalation stage completed in April 2023, the ongoing trial is now in the expansion cohort stage.

The trial (NCT05392751) is examining the safety, tolerability, and preliminary efficacy of intravitreal EA-2353, a first-in-class small molecule that selectively activates endogenous retinal stem and progenitor cells to potentially preserve and restore visual function.

The trial has enrolled 14 patients with RP due to any pathologic genetic mutation and is being conducted across five US sites.

The first patient started treatment in July 2022 and topline interim data is anticipated in early 2024.

Matthias Steger, PhD, MBA, CEO of Endogena Therapeutics: “Getting this far in a remarkably short time is testament to the outstanding execution of our clinical team in collaboration with InFocus Clinical Research. There’s a tremendous enthusiasm surrounding our trial and completing enrollment ahead of schedule has only been possible thanks to the invaluable contribution of the patients, their families, the investigators and their study staff. We are all driven by the hope of finding a treatment for this rare and devastating disease.”